Palacios joined Leverkusen in January 2020 from Argentinian giants River Plate and has since made 110 Bundesliga appearances, including 24 in the 2023/24 season when the club celebrated a famous unbeaten Bundesliga and DFB Cup double under Xabi Alonso.
Having extended his deal, which was originally set to run to 2028, to June 2030, the club's managing director for sport Simon Rolfes said: "Pala's value to us has increased from season to season. His vast international experience as well as his outstanding strategic and individual qualities as a number six make him a key element in the construction of another highly ambitious team."