The Guinea international - capped 26 times by his country - finished runner-up to Atalanta's Ademola Lookman (formerly of RB Leipzig) last season and the BVB forward faces some stiff opposition this time around as he looks to lift the prize for the first time.
Guirassy has been in typically prolific form so far this season, scoring four goals in just six Bundesliga appearances to date and also hitting the target in the DFB Cup and UEFA Champions League.
Last term, the 29-year-old weighed in with an incredible 21 top-tier goals and was the joint-top scorer in the Champions League, finding the net 13 times in 14 games as the Black-Yellows reached the tournament's quarter-finals.
Watch: Guirassy double downs Union Berlin