The 2014 World Cup winner has been nursing a calf injury since the end of the Bundesliga season, but his return to action for Die Nationalelf - after an almost two-year absence - now looks immiment.
As a result, Hoffenheim stopper Oliver Baumann is set to lose his status as Germany's undisputed number 1, despite playing in the side's recent friendly match against the USA in Chicago.
Baumann, who has hardly put a foot wrong for Germany, earned praise from Nagelsmann for his professionalism in their 2-1 win against the World Cup hosts on Saturday.